Pre - Implantation Genetic Testing - PGT

Pre-implantation Genetic Testing (PGT) injection can reduce this risk by determining if your embryos are healthy before implanting them inside your uterus. It could also help you avoid miscarriages because it can detect chromosomal abnormalities before implantation.

PGT-A - PGS

PGT-A (formerly called PGS) is a genetic test performed on embryos to identify numerical chromosomal abnormalities (aneuploidy). This test is a genetic study of the embryo produced during IVF treatment and can help you have a healthy baby.Simultaneous testing of the entire set of chromosomes of an embryo on the day 5 of development by NGS method (Next generation sequencing) before the embryo is transferred into the uterus.

Who should use PGT-A?

PGT-A is especially recommended for patients with:

  • Advanced maternal age: 35 years old and above
  • Recurrent miscarriages: couples who have had two or more miscarriages
  • IVF failures: two or more IVF failures
  • Male factor infertility: a low quantity and/or quality of sperm

Why use PGT-A?

  • Reduced miscarriage rates.
  • Higher pregnancy rates per transfer.
  • Fewer cycles of IVF treatment needed – reducing both the time and financial cost
  • Greater chance of having a healthy child.
  • Fewer wasted transfers (implantation failure).
  • Optional Single Embryo Transfer (SET).
  • Fewer ‘wasted’ transfers with aneuploid embryos that could never lead to a successful pregnancy
  • Optional Single Embryo Transfer (SET) to significantly reduce the likelihood of a multiple-gestation pregnancy

How does it work ?

PGT-M - PGD

PGT-M (formerly PGD) helps significantly decrease the chance of having a child with an inherited genetic disorder by analysing embryos before transfer and identifying those that do not carry the altered, disease-causing gene.

Is PGT-M for you?

This test is recommended if:

  • You already have a child affected by a monogenic disease.
  • You or your partner are carriers or have been diagnosed with one of these diseases or if there is a family history

How does it work ?

HLA matching

Some genetic conditions like thalassemia can only be cured permanently by bone marrow transplant or other similar treatment. For this, HLA matched donor is required. Getting a matching donor is extremely difficult. The couples who already have an affected child can conceive a not affected child, and that too a matching donor for the affected sibling.

Process of PGT

IVF process is a per standard protocol. When the embryos are ready, they can be biopsied, and genetic sample collection can be done on Day 3 or Day 5. For collecting cells for genetic analysis, a Laser is used to make a small opening in the outer wall of the embryo. A suction pipette gently sucks one or more cells from the embryo. Cells are sent for genetic analysis. Embryos are totipotent at this stage, so removing these cells will not harm the embryo.

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